{"id":2644,"date":"2025-03-17T13:15:00","date_gmt":"2025-03-17T04:15:00","guid":{"rendered":"https:\/\/pf-form.kek.jp\/sbrc\/?p=2644"},"modified":"2025-03-17T18:24:03","modified_gmt":"2025-03-17T09:24:03","slug":"seminar22","status":"publish","type":"post","link":"https:\/\/pf-form.kek.jp\/sbrc\/seminar22\/","title":{"rendered":"SBRC International Cryo-EM Seminar No.22"},"content":{"rendered":"\n
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\u201cSBCloud: A Cloud-based Platform for Cryo-EM Structure Determination and Training from SBGrid<\/strong>\u201d<\/h2>\n<\/blockquote>\n\n\n\n
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Date and Time<\/h2>\n\n\n\n
4:00 PM – 5:30 PM Wednesday, April 16th<\/sup>, 2025<\/p>\n\n\n\n
Location<\/h2>\n\n\n\n
Hybrid (Zoom and KEK CryoEM building)<\/p>\n\n\n\n
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Speakers:<\/h2>\n\n\n\n
Jason Key, PhD<\/h2>\n\n\n
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Associate Director of Technology & Innovation, SBGrid Consortium Lecturer on Biological Chemistry and Molecular Pharmacology, Harvard Medical School<\/p>\n\n\n\n
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Abstract<\/h2>\n\n\n\n
The ever-growing demand for computational power, data storage, and access to cutting-edge scientific software can be a formidable challenge for structural biology research labs. SBGrid, an international research computing consortium based at Harvard Medical School aims to break down technological barriers in structural biology and accelerate discoveries. To support this mission, SBGrid provides an extensive suite of scientific software, expert domain-specific support, computing hardware solutions, and training for scientists investigating molecular mechanisms at the atomic level. Recognizing the increasing computational demands of cryo-EM structure determination, we developed SBCloud\u2014an AWS infrastructure-as-code high-performance computing environment designed for advanced analysis and visualization of structural biology data. We have used SBCloud to host global cryo-EM workshops, fostering collaboration and hands-on training in high-performance computing for structural biologists. We recently offered SBCloud to the SBGrid community on a limited basis, enabling researchers to tackle cryo-EM and Cryo-ET structure determination projects and enabling us to test our platform at scale. In this presentation, I will share insights and lessons learned from our experience in training and supporting the global cryo-EM and Cryo-ET research community and discuss the role of cloud resources in computational structural biology.<\/p>\n\n\n\n
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Profile<\/h2>\n\n\n\n
1997 BS Biochemistry Purdue University, West Lafayette, IN, USA<\/p>\n\n\n\n
2004 Ph.D, Time-resolved Laue diffraction of Bacterial sensor proteins University of Chicago, Chicago IL, USA<\/p>\n\n\n\n
2004-2007, Postdoc, Femtosecond laser spectroscopy of sensor proteins Free University Amsterdam\/University of Amsterdam, Netherlands<\/p>\n\n\n\n
2007-2012, Postdoc, Inhibition of HIF-2alpha with small molecules University of Texas Southwestern, TX USA<\/p>\n\n\n\n
2012-2014, Structural Biology Computing Specialist, Harvard 2014-current, Lecturer on Biological Chemistry and Molecular Pharmacology 2014-current, Associate DIrector of Technology and Innovation, SBGrid Consortium<\/p>\n\n\n\n
![\"\"](\"https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2025\/03\/Jason_Key-CryoEMSymposium_Photo.jpg\")
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