{"id":2656,"date":"2025-04-22T09:22:36","date_gmt":"2025-04-22T00:22:36","guid":{"rendered":"https:\/\/pf-form.kek.jp\/sbrc\/?p=2656"},"modified":"2025-04-22T14:32:36","modified_gmt":"2025-04-22T05:32:36","slug":"seminar23","status":"publish","type":"post","link":"https:\/\/pf-form.kek.jp\/sbrc\/seminar23\/","title":{"rendered":"SBRC International Cryo-EM Seminar No.23"},"content":{"rendered":"\n
<\/p>\n\n\n\n
\n
\u201cThe structure, dynamics and function of Adaptive Immune Receptors <\/strong>\u201d<\/h2>\n<\/blockquote>\n\n\n\n
_<\/p>\n\n\n\n
Date and Time<\/h2>\n\n\n\n
4:00 PM – 5:30 PM Friday, May 9th<\/sup>, 2025<\/p>\n\n\n\n
Location<\/h2>\n\n\n\n
Hybrid (Zoom and KEK CryoEM building)<\/p>\n\n\n\n
<\/p>\n\n\n
\n\n\n
Speakers:<\/h2>\n\n\n\n
Daron Standley, PhD<\/h2>\n\n\n\n
Research Institute for Microbial Diseases (RIMD), Osaka University (Professor)<\/p>\n\n\n\n
\n
<\/div>\n\n\n\n
<\/div>\n<\/div>\n\n\n\n
\n<\/figure>\n\n\n\n
<\/p>\n<\/div>\n\n\n\n
Abstract<\/h2>\n\n\n\n
Adaptive immune receptors (AIRs)<\/strong> consist of B cell receptors (BCRs)\u2014also known as antibodies in their soluble form\u2014and T cell receptors (TCRs), which remain anchored to the plasma membrane of T cells. AIRs are unique among human proteins in that they are generated by the combinatorial assembly of genes, leading to an extraordinary diversity of expressed proteins that undergo positive and negative selection throughout our lives. The diversity is so great that any two humans typically share only a few percent of their BCRs or TCRs in a routine blood draw. In spite of this incredible diversity, different individuals respond to vaccines in much the same way within days\u2014a remarkable example of robustness and functional convergence. I will describe one particularly interesting example of convergent responses that, unexpectedly, enhances SARS-CoV-2 infection. I will also show how BCR and TCR sequencing of peripheral blood can be used to diagnose a wide range of diseases, including infections, autoimmunity, and cancer. If time permits, I will also introduce a model of how T cells sense antigens\u2014derived from unbiased molecular dynamics simulations and validated experimentally.<\/p>\n\n\n\n
<\/p>\n\n\n\n
Profile<\/strong><\/h2>\n\n\n\n
1998\u20132003<\/strong>: Schr\u00f6dinger, Inc.<\/em> (New York, USA) \u2014 Scientific Software Developer<\/strong> Engaged in the development of scientific software, including flexible docking.<\/p>\n\n\n\n
2003\u20132008<\/strong>: Osaka University, Institute for Protein Research, Protein Data Bank Japan (PDBj)<\/em> \u2014 Senior Researcher<\/strong> Developed tools for structure-based searching at PDBj.<\/p>\n\n\n\n
2008\u20132014<\/strong>: Osaka University, Immunology Frontier Research Center (IFReC)<\/em> \u2014 Specially Appointed Associate Professor<\/strong> Launched the systems immunology lab where I worked on modeling immune responses.<\/p>\n\n\n\n
2014\u20132016<\/strong>: Kyoto University, Institute for Virus Research<\/em> \u2014 Professor<\/strong> Developed tools for high-throughput BCR and TCR modeling.<\/p>\n\n\n\n
2014\u2013Present<\/strong>: Osaka University, Research Institute for Microbial Diseases, Division of Genome Informatics<\/em> \u2014 Professor<\/strong> I worked in disease diagnosis using adaptive immune receptors.<\/p>\n\n\n\n\n\n\n\n
![\"\"](\"https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2025\/04\/Daron-Standley-PhD-1.jpg\")
<\/figure>\n\n\n\n