{"id":3009,"date":"2025-09-04T11:49:47","date_gmt":"2025-09-04T02:49:47","guid":{"rendered":"https:\/\/pf-form.kek.jp\/sbrc\/?p=3009"},"modified":"2025-09-05T12:45:25","modified_gmt":"2025-09-05T03:45:25","slug":"seminar27","status":"publish","type":"post","link":"https:\/\/pf-form.kek.jp\/sbrc\/seminar27\/","title":{"rendered":"SBRC Seminar (International Cryo-EM Seminar No.27)"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<h2 class=\"wp-block-heading\">\u201cEnzymes: From Natural Diversity to Optimized Tools for Biomedical Applications \u2013 The Case of Antimicrobial Enzymes\u201d<\/h2>\n<\/blockquote>\n\n\n\n<p> _<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Date and Time<\/h2>\n\n\n\n<p style=\"font-size:25px\">10:00 AM &#8211; 11:30 AM Wednesday, September 24<sup>th<\/sup>, 2025<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Location<\/h2>\n\n\n\n<p style=\"font-size:25px\">Onsite\uff08SBRC building\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-size:30px\">Speakers: Dr. Claire STINES-CHAUMEIL<\/h2>\n\n\n\n<p class=\"has-medium-font-size\"><strong>Associate Professor<\/strong><br><strong>Paul Pascal Research Centre<br>University of Bordeaux, FRANCE<\/strong><\/p>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-ad2f72ca wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"225\" src=\"https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2025\/09\/Claire-STINES-CHAUMEIL.jpeg\" alt=\"\" class=\"wp-image-3027\" style=\"width:278px;height:auto\" srcset=\"https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2025\/09\/Claire-STINES-CHAUMEIL.jpeg 225w, https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2025\/09\/Claire-STINES-CHAUMEIL-150x150.jpeg 150w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/><\/figure>\n\n\n\n<p><br><\/p>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Enzymes are protein catalysts that can accelerate reaction rates by up to 1021-fold without altering the thermodynamic equilibrium. They are ubiquitous in biochemical transformations and often exhibit remarkable selectivity, a property rarely achieved by artificial catalysts. Enzymes have broad applications across various industries, including agri-food, textiles, PET degradation, drug synthesis, and medicine.<br>My research focuses on understanding the structure-function relationship of enzymes and elucidating their mechanisms, particularly those relevant to biomedical and biotechnological applications. I then optimize natural catalysts through genetic and protein engineering to enhance their suitability for specific uses, such as glucose biosensors, catheters, immunosensors, and disinfection.<br>In my talk, I will focus on microbicidal enzymes naturally involved in human innate immunity. I will present the strategies used to identify key enzymes and characterize their biochemical and physicochemical properties. These enzymes have been optimized to exhibit ideal antimicrobial properties for biomedical applications, such as combating nosocomial infections.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity is-style-dots\" \/>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-white-color has-cyan-bluish-gray-background-color has-text-color has-background\"><a href=\"https:\/\/pf-form.kek.jp\/sbrc\/registration-for\/\" data-type=\"link\" data-id=\"https:\/\/pf-form.kek.jp\/sbrc\/registration_for_international_seminar\/\" target=\"_blank\" rel=\"noreferrer noopener\">Click here to apply<\/a><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>\u201cEnzymes: From Natural Diversity to Optimized Tools for Biomedical Applications \u2013 The Case of Antimicrobial En [&hellip;]<\/p>\n","protected":false},"author":26,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-3009","post","type-post","status-publish","format-standard","hentry","category-kek-cryoem"],"_links":{"self":[{"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/posts\/3009","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/comments?post=3009"}],"version-history":[{"count":7,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/posts\/3009\/revisions"}],"predecessor-version":[{"id":3033,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/posts\/3009\/revisions\/3033"}],"wp:attachment":[{"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/media?parent=3009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/categories?post=3009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/tags?post=3009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}