{"id":3453,"date":"2026-06-04T09:24:23","date_gmt":"2026-06-04T00:24:23","guid":{"rendered":"https:\/\/pf-form.kek.jp\/sbrc\/?p=3453"},"modified":"2026-06-05T09:03:57","modified_gmt":"2026-06-05T00:03:57","slug":"seminar33","status":"publish","type":"post","link":"https:\/\/pf-form.kek.jp\/sbrc\/seminar33\/","title":{"rendered":"SBRC International Cryo-EM Seminar No.33"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<h2 class=\"wp-block-heading\">\u201cStructure of the human voltage-gated proton channel Hv1 in complex with the pore-forming toxin LukAB.\u201d<\/h2>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\"> _<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Date and Time<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:25px\">4:00 PM &#8211; 5:30 PM Thursday, June 25<sup>th<\/sup>, 2026<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Location<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:25px\">Onsite\uff08CryoEM building\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-size:30px\">Speaker<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1417\" height=\"1639\" src=\"https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2026\/06\/YusukeSekiguchi-.jpg\" alt=\"\" class=\"wp-image-3457\" style=\"aspect-ratio:0.8645588755588434;width:223px;height:auto\" srcset=\"https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2026\/06\/YusukeSekiguchi-.jpg 1417w, https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2026\/06\/YusukeSekiguchi--259x300.jpg 259w, https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2026\/06\/YusukeSekiguchi--644x745.jpg 644w, https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2026\/06\/YusukeSekiguchi--768x888.jpg 768w, https:\/\/pf-form.kek.jp\/sbrc\/wp-content\/uploads\/sites\/39\/2026\/06\/YusukeSekiguchi--1328x1536.jpg 1328w\" sizes=\"auto, (max-width: 1417px) 100vw, 1417px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-size:28px\">Yusuke Sekiguchi<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Dept. of Structural Biology, Department of Host-Microbe Interactions,<br>St. Jude Children&#8217;s Research Hospital, Memphis, TN<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Staphylococcus aureus LukAB is a bicomponent pore-forming toxin that targets human immune cells. Although human voltage-gated proton channel (hHv1) and CD11b\/CD18 have been implicated in LukAB-mediated cell targeting, the structural basis of host receptor recognition remains unclear. Here, we analyzed hHv1 in complex with LukAB variants CC8 and CC45 to reveal how LukAB recognizes Hv1 and to provide the first structural insight into hHv1.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity is-style-dots\" \/>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-white-color has-cyan-bluish-gray-background-color has-text-color has-background\"><a href=\"https:\/\/pf-form.kek.jp\/sbrc\/registration_for_internationalseminar\/\" data-type=\"link\" data-id=\"https:\/\/pf-form.kek.jp\/sbrc\/registration_for_international_seminar\/\" target=\"_blank\" rel=\"noreferrer noopener\">Click here to apply<\/a><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>\u201cStructure of the human voltage-gated proton channel Hv1 in complex with the pore-forming toxin LukAB.\u201d _ Date [&hellip;]<\/p>\n","protected":false},"author":26,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-3453","post","type-post","status-publish","format-standard","hentry","category-kek-cryoem"],"_links":{"self":[{"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/posts\/3453","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/comments?post=3453"}],"version-history":[{"count":7,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/posts\/3453\/revisions"}],"predecessor-version":[{"id":3471,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/posts\/3453\/revisions\/3471"}],"wp:attachment":[{"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/media?parent=3453"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/categories?post=3453"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pf-form.kek.jp\/sbrc\/wp-json\/wp\/v2\/tags?post=3453"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}