MicroED: conception, practice and future opportunities
Date:
9:00 AM – 11:00AM Monday, November 7th, 2022 (JST),
Location: Online Zoom Meeting
Speaker
Prof. Tamir Gonen, PhD,
Biological Chemistry and Physiology,
David Geffen School of Medicine,
University of California, Los Angeles.
Investigator of Howard Hughes Medical Institute
Abstract
Dr Gonen is an expert in electron crystallography and cryo-EM. In 2011, he began developing a new method for structural biology, currently widely known as MicroED (Microcrystal Electron Diffraction). With this method, he has pushed the boundaries of cryo-EM and determined several previously-unknown-structures at resolutions close to 1Å. In 2013, the method of MicroED began to gain momentum with the demonstration that protein structures could be determined from 3D crystals using electron diffraction. Over the past decade several technological milestones were developed, optimized, and described. Currently, several laboratories and facilities regularly collect MicroED data and solve important structures from materials, small molecules, natural products to peptides, soluble proteins and importantly membrane proteins. In this seminar, Dr. Gonen will present the history of MicroED from its beginning, focusing on its practice, and discuss where the method is going in the coming years and where we could see its biggest impact in the coming years.
Profile:
2002 – 2005 Postdoctoral fellow, Harvard Medical School.
2005 – 2010 Assistant Professor, University of Washington School of Medicine.
2009 – 2011 Early Career Scientist, Howard Hughes Medical Institute.
2010 – 2011 Associate Professor with Tenure, University of Washington School of Medicine.
2011 – 2017 Group Leader, Janelia Research Campus, Howard Hughes Medical Institute.
2017 – Current Professor, Biological Chemistry and Physiology, David Geffen School of Medicine,
University of California, Los Angeles.
2017 – Current Investigator, Howard Hughes Medical Institute.