“Structural insights into the peroxisomal import machinery”
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Date:
4:00 PM – 5:30 PM Friday, April 7th, 2023 (JST),
Location: CryoEM-Lab KEK and Zoom
Speaker
Prof. Christos Gatsogiannis, PhD
Institute for Medical Physics and Biophysics and
Center for Soft Nanoscience (SoN),
University of Münster, Germany.
Abstract
Our research focuses on the molecular understanding of peroxisomal biogenesis. Peroxisomes are dynamic small organelles found in almost all eukaryotes and are capable of performing a plethora of crucial metabolic functions. Peroxisomal enzymes are synthesized on free cytoplasmic ribosomes and later imported into the peroxisomal lumen by the peroxisomal import machinery. However, the main characteristics of the peroxisomal import process remain poorly understood. Our research aims to characterize and visualize these processes using cryo-electron microscopy (single particle analysis and tomography) and biochemical and biophysical methods to understand, in order to provide the necessary mechanistic insights into this central mechanism. In this lecture, Prof. Gatsogiannis will talk about the current structural work of his group on the peroxisomal import machinery.
Profile:
2005 Master (Biology), University of Mainz, Germany
2009 Ph.D. (Biology), University of Mainz, Germany, 2009
2010 Postdoctoral Researcher with Prof. J. Markl, University of Mainz, Germany
2010-2015 Postdoctoral Researcher with Dr. S. Raunser,
Max Planck Institute for Molecular Physiology, Germany
2016-2020 Tenured Project Group Leader,
Max Planck Institute of Molecular Physiology, Germany
2020- Full Professor, University of Münster, Germany
2023- Co-Director, Center for Soft Nanoscience, Münster, Germany